Pediatric Vaccine Adjuvants
نویسندگان
چکیده
منابع مشابه
Novel Vaccine Adjuvants
Vaccines still remain the most successful method for protection and eradication against diseases. However, to avoid harmful effects associated with whole organism vaccines, new vaccine candidates are composed of parts of an organism, and therefore these are weakly immunogenic. Adjuvants are essential components of vaccines that nonspecifically stimulate the immune system, particularly the innat...
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A huge amount of evidence has been made available on various adjuvants as immunological auxiliaries. Very few of them, however, have made it into commercial vaccines. Their defining properties and uses are discussed in the following mini-review. WHAT IS AN ADJUVANT? In Freund's words [1] an adjuvant should “evoke very abundant serum antibody production sustained for an unexpectedly long time”. ...
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Mucosal vaccination, capable of inducing protective immune responses both in the mucosal and systemic immune compartments, has many advantages and is regarded as a blue ocean in the vaccine industry. Mucosal vaccines can offer lower costs, better accessability, needle-free delivery, and higher capacity of mass immunizations during pandemics. However, only very limited number of mucosal vaccines...
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Vaccines represent an outstanding success story in modern medicine and are responsible for a huge reduction in morbidity and mortality worldwide, but it is clear that improvements are necessary to enable the development of successful vaccines against somedifficult pathogens, includinghuman immunodeficiency virus (HIV), hepatitis C virus (HCV) and respiratory syncytial virus (RSV). Vaccine impro...
متن کاملAdjuvants in tuberculosis vaccine development.
Tuberculosis remains a major public health problem around the world. Because the Mycobacterium bovis Bacilli-Calmette-Guerin (BCG) vaccine fails to protect adults from pulmonary tuberculosis, there is an urgent need for improved vaccine formulations. Unlike BCG, recombinant vaccines purified from bacterial expression vectors, as well as naked DNA, require an additional adjuvant. Recent improvem...
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ژورنال
عنوان ژورنال: Pediatric Infectious Disease Journal
سال: 2015
ISSN: 0891-3668
DOI: 10.1097/inf.0000000000000893